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Jaundice sign and symptoms of the patients and management

Jaundice definition , Type , sign , symptoms and management .


Definition of jaundice


It is a clinical condition described by yellow discolouration of skin,  sclera and mucous membrane due to increase serum bilirubin more than 3mg/dl. 

Type of Jaundice

  1. Prehepatic / hemolytic jaundice
  2. Hepatic /hepatocellular jaundice
  3. Post hepatic/obstructive jaundice 

Prehepatic or hemolytic jaundice occurs due to breakdown  of Red Blood Cell and hepatic uptake of bilirubin or impaired bilirubin conjugation. 
  • Hemolytic anaemia 
  • Thalassaemia
  • Pernicious anaemia
  • Gilbert syndrome
  • Crigler-Najjar Syndrome
  • Neonatal jaundice 
  • Drug induced- Rifampicine


Hepatic or hepatocellular jaundice :
  • Viral Hepatitis due to viral infection such as Hepatitis A virus
  • Hepatitis B virus 
  • Hepatitis C virus
  • Hepatitis D virus
  • Hepatitis E virus
  • Epstein Bar virus
  • Cytomegalo virus
  • Dengue virus etc

  • Drug induced- Rifampicin, Pyrazinamide, phenothiazines
  • Wilson's disease 
  • Hemochromatosis 
  • Dubin johnson syndrome
  • Rotor syndrome

Obstructive or post hepatic jaundice : this type of jaundice occurs due to obstruction of normal bilirubin pathway.
  • Carcinoma of head of pancreas 
  • Stone in bile duct or choledocolithiasis
  • Cholangiocarcinoma
  • Periampulary carcinoma
  • Alcoholic hepatitis 
  • Pregnancy 
  • Biliary atresia
  • Worm in Bile duct
  • Sclerosing cholangitis
  • Biliary cirrhosis 


Congenital hyperbilirubinaemia(non haemolytic)
  • Gilbert's syndrome
  • Crigler najjar syndrome
  • Dubin jhonson syndrome 
  • Rotor's syndrome

Sign and symptoms of Jaundice and important point for diagnosis of jaundice 

  • Yellow coloration of eye(sclera), skin,  tongue,  palm and sole
  • Nausea  
  • Vomiting 
  • Anorexia
  • Yellowish, pale or dark color stool
  • Yellow color urine
  • Itching in Obstructive jaundice 
  • Consanguinity marriage (genetic jaundice) 




Jaundice sign and symptoms of the patients and management Jaundice sign and symptoms of the patients  and management Reviewed by Noman Islam Nirob on Monday, July 20, 2020 Rating: 5

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